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Moreover, the thioredoxin system, dependent on thioredoxin reductase (TrxR), directly influences the redox state of cysteine residues in NF-B subunits, modulating their ability to bind DNA and regulate transcription [67]

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JAK, Janus Kinases

155,156 While corticosteroids have shown limited efficacy and potential adverse effects in clinical trials, NSAIDs, particularly those with selective cyclooxygenase-2 inhibition, have demonstrated some protective effects in experimental models

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this loss of stable ECD-ECD interaction was associated with increased motions of the RAMP-proximal loops of the CTR ECD (7-angstrom motion, measured at C of E123 ECD