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doi: 10.1016/S0140-6736(20)32705-7 5 MehandruSMeradM

Once inside mitochondria, they create double-strand breaks in the mutant mtDNA, leading to its degradation and selectively enriching wild-type mtDNA, thereby lowering the mutational load below the pathogenic threshold

2019, 11:e10473

They suggest lifestyle changes to improve symptoms and quality of life

This predictable and targeted mode of action represents one of the key benefits of stem cell-derived peptides, offering regenerative potential without the procedural complexity of cell-based therapies

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