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IL-6 Signal Pathways [2] In classic signaling, IL-6 binds to the membrane-bound IL-6R (mIL-6R), leading to the activation of a signal-transducing homodimer involving the glycoprotein 130 (gp130) receptor chain

By targeting the cell cycle inhibitors Cdkn1a and Ccng2 , miR-302b can release cell cycle arrest, restore the proliferation ability of senescent cells, and significantly reverse the aging phenotype of mice