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doi: 10.1007/BF02152299

This hypothesis has been supported by studies in mice, rats, and non-human primates, demonstrating -syn propagation from the periphery to the central nervous system (CNS) and vice versa, as well as from the brain to other organs (Luk et al., 2012

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The inhibition was probably unspecific, as it acted on ERK-2 and p21ras of T cells, however proteolytic-dependent, evoked by selective cysteine protease inhibitor in further experiments

Cao Y, Arbiser J, DAmato RJ, DAmore PA, Ingber DE, Kerbel R, Klagsbrun M, Lim S, Moses MA, Zetter B