glutathione peroxidase 1 heme Reappraising oxygenase-1 as a ferroptosis modulator in atherosclerosis: a mechanism-focused review Phospholipid Hydroperoxide Glutathione Peroxidase -

The most potent compound 20 ( 59 ) possesses a chlorinator motif at the C3 position of the flavanone ring with an IC 50 of 370 nM (Figure 10)

Flow cytometry analysis showed that BSO induced more than two times the amount of H2AX staining, which demonstrated higher levels of DNA damage after cisplatin exposure in the presence of BSO (Figure 3d)

Combining these scores increases the explained variance to about 3.7% for categorical outcomes, which is comparable to conventional genome-wide PGSs but with better biological interpretability

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