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For doses under 20 units, a 0.3 mL or 0.5 mL syringe with 1-unit markings gives better precision than a 1 mL syringe marked in 2-unit steps

One of the major drawbacks is their large molecular mass of about 150 kDa, responsible for slow kinetics and limited tumor penetration with only approximately 20% of the administered dose reaching the tumor site [85]

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