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Pro-inflammatory macrophages commonly increase glycolysis and reprogram the TCA cycle and mitochondrial electron transport chain to support rapid cytokine production, reactive oxygen species (ROS) generation, and antimicrobial activity, whereas pro-resolving macrophages more often engage in mitochondrial respiration, fatty acid oxidation, and biosynthetic programs linked to efferocytosis and tissue repair ( Figure 1 )

Because of the dominant character of SOD1-dependent ALS, SOD1 WT is present in the majority of fALS cases

Recently, the increased level of plasma TMAO has been reported to contribute to renal dysfunction and TMAO is reversely correlated with eGFR in the patients with type 2 diabetes

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