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To characterize HCAR1 signaling pathways, a study using a cell line designed to express human HCAR1 (CHO-K1) showed activation of extracellular signal-regulated kinases (ERK1/2) via HCAR1 in response to lactate and DHBA and sensitivity to the G i protein inhibitor pertussis toxin ( i protein was central in the regulation of HCAR1-activated ERK1/2 phosphorylation via extracellular Ca 2+ , protein kinase C (PKC), and insulin-like growth factor-1 receptor (IGF-1R) activation

Some evidence also points to potential anti-aging and muscle-preserving effects when paired with exercise and proper nutrition

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The H 2 O 2 decomposition is believed to occur in two steps (Figure 3, steps 1 and 2) [45, 50, 52]

[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Meister A

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