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The aberrant accumulation of A and hyperphosphorylated Tau proteins on mitochondria results in mitochondrial respiratory chain complex I activity, impaired mitochondrial membrane potential (MMP), and massive production of reactive oxygen species (ROS), which in turn affects mitochondrial function ( A number of studies have demonstrated that there are extensive mitochondrial abnormalities in the brains of AD patients and animal models (Swerdlow, 2018)

When VB12 deficiency is diagnosed, treatment options include a standardised replacement regimen or close monitoring of VB12 levels and replacement as required

doi: 10.3389/fimmu.2021.703574

Understanding these potential mechanisms helps clinicians counsel patients appropriately and distinguish between expected treatment effects and concerning adverse reactions

Staying hydrated and using over-the-counter pain relievers can often mitigate this discomfort

10.1128/MCB.20.13.4699-4707.2000 172 LiX.ChauhanA.SheikhA