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Vitamin B12 treatment strongly affects the brain metabolome and transcriptome, and partially compensates for the effects of Tbx1 haploinsufficiency Given the ability of vB12 prenatal treatment to rescue diverse phenotypes caused by Tbx1 haploinsufficiency (13, 14, 15), we asked whether this occurs through metabolic mechanisms that are transcriptionally regulated by TBX1 or by rebalancing the brain metabolic profile of Tbx1 +/ mice

Its not worth it to wait around and see if you get a nutritional deficiencywhen it comes to vitamin B 12 , its best for vegans to supplement or eat fortified foods as soon as they go vegan

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The availability of therapeutic hydroxocobalamin to cells

For people with severe needle phobia, the convenience advantage is not trivial

Brasky, 2017) or used pre-diagnostic circulating B12 in prospective cohorts with sufficient lead time to reduce reverse causation concerns (Fanidi, 2019)