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Additionally, flavonoids modulate key enzymes such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, xanthine oxidase, and cyclooxygenase-2, which are major sources of ROS involved in chemotherapy resistance (Passaniti et al., 2022

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Chemokines and cytokines released from within the liver attract macrophages/ monocytes, lymphocytes, activated neutrophils and fibroblasts to the site of inflammation

It also increased the expression of CD38 at the mRNA level by activating the Janus kinase signal transducer and transcription activator (JAK-STAT) pathway ( The recovery of CD38-deficient mice after closed head injury (CHI) was significantly lower than that of wild-type (WT) mice, and the object recognition ability of CD38-deficient mice was significantly lower than that of the WT mice