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Other studies have also shown that chronic administration of rotenone over a long period can increase nitric oxide and lipid peroxidation products in the brain cortex and striatum in rats, which then clearly mimic parkinsonian behavioral symptoms such as akinesia and rigidity

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The animal science is real, but calling it 'proven' is a stretch when 99.7% of the research is in rats

Results vary by individual, skin type, and consistency of use it is not an overnight fix, but it is a legitimate ingredient backed by growing research

and nutrition and clinical medicine can translate these findings into implementable dietary recommendations or complementary therapeutic programs, which can then be verified in clinical trials

Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum