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All samples underwent untargeted metabolomic analysis using UPLC-QTOF/MS for comparative profiling among MA-exposed rats versus control rats, MA-exposed rats versus methanol-exposed rats, and MA-exposed patients versus healthy controls

Several meta-analyses have reported an 8%-15% decrease in the risk of developing type 2 diabetes mellitus with each 100 mg-increment in dietary magnesium intake (74-77)

This conversion can be initiated by plant-derived myrosinase, released upon tissue damage (e.g., chewing), or by microbial myrosinase in the gut (43)

Acknowledgments The authors acknowledge the support of the Department of Veterinary Clinical Sciences (VCS) Core Lab, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA

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The results reported here are consistent with previous orthogonal studies where long-lived genetic mutants of the insulin-like signaling pathway in C