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IDH1/2 use NADP + as a cofactor and conduct a reversible reaction, while IDH3 uses NAD + as a cofactor and conducts irreversible conversion

The miR-181c loss can protect the heart from I/R injury by modulating calcium transport through the upregulation of mitochondrial calcium uptake 1 (MICU1) (98)

a PEG-based polymeric chain is a linear poly(ethylene glycol) chain, of which one end is connected to the branching core and the other to a hyperbranched dendritic moiety

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Their advantage lies in the ability to sensitively capture the early cascade of events, ranging from impaired mitochondrial fatty acid oxidation to transport defects and tubular metabolic imbalance, thereby complementing the molecular trajectory of DKD that is not adequately reflected by conventional UACR measurements (Table 1)