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DAG remains membrane-bound and promotes protein kinase C (PKC) activation, whereas IP diffuses into the cytoplasm and binds IP receptors (IPRs) on the endoplasmic reticulum (ER), triggering Ca release 25

GSSG sensitized hepatocytes to TNF-mediated cytotoxicity via the induction of IKK- glutathionylation and subsequent NF-B suppression NF-B activation plays a critical role in protecting hepatocytes from TNF-mediated cytotoxicity

Glutathione is synthesized in the liver and is present in every cell, where it plays a crucial role in various biological processes, including: Antioxidant Defense : Glutathione neutralizes harmful free radicals, which can damage cells and contribute to various health issues

Cell 171 , 15451558.e18 (2017)

The model suggests that this decrease is caused by the sequestration of Keap1 in the complex with Nrf2 due to its interaction with DEM