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TBI-induced neuroinflammation further intensifies this metabolic reprogramming, with activated microglia releasing pro-inflammatory factors like IL-6 and TNF, enhancing glycolysis while suppressing OXPHOS through TLR signaling pathways (190)

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Assessment was again carried out at the end of the subsequent 24 h period

in the remission phase, they maintain gut microbial balance and promote immune tolerance to reduce recurrence risk

Importantly, despite recent research indicating distinct findings regarding the 40 Hz effect, particularly concerning amyloid load in AD 21,22 , multiple studies in both mouse models and humans have consistently affirmed the beneficial effects of GENUS on disease pathology 18,19,23,24,25,26,27,28,29,30