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In rodents, CYP induction decreases ITZ-associated hepatotoxicity while CYP inhibition increases toxicity, so either the parent compound or metabolites produced by an alternative pathway likely cause toxicity (32, 40)

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doi: 10.1111/j.1464-5491.1988.tb01047.x 26 FagiusJBrattbergAJamesonSBerneC

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Excessive alcohol consumption can cause fat deposit build-up, inflammation, scarring, and liver cell deathall of which are significant risk factors for liver disease and cancer