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Clinical outcomes were assessed using Aberrant Behavior Checklist - Community (ABC-C) at baseline, week 5, and week 10, with no biological or imaging analyses performed

In addition, the classical metabolic drug metformin increases oocyte maturation rate and early embryonic developmental potential in aged mice cultured in an in vitro maturation system through a mechanism involving SIRT3-mediated deacetylation of SOD2, which mitigates mitochondrial damage [362]

Moreover, FOXO4-DRI significantly decreased the viability of senescent Leydig cells and dramatically increased their apoptosis rate from 10% to 27%

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Simultaneous treatment with LPS and HNE significantly increased Nrf2 activation, compared to LPS alone (Fig

After three washes with PBS, the cells were incubated with an Oil red O solution (Sigma-Aldrich) for 10 min