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Our work provides an understanding of how age-associated cognitive decline in older humans is linked to glutathione deficiency, increased oxidative stress, mitochondrial dysfunction, abnormal glucose metabolism and insulin resistance, inflammation and low levels of neurotrophic or neuron-supporting factors, and that supplementing GlyNAC reverses these defects and improves cognition. Human studies only permit measurements at the whole-body level, so in this study the researchers studied mice to investigate defects directly in the aging brain

Antioxidants 7 , 159 (2018)

Several HDT drugs used in the treatment of TB, including statins, macrocyclic lactones, and TKI, have received approval by the US Food and Drug Administration for other clinical applications, underscoring their favorable safety profiles

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The FDA moved these peptides to Category 2 primarily due to a lack of large-scale, randomized, placebo-controlled human trials demonstrating their safety and efficacy

Sirtuin 1, a diagnostic protein marker and its relevance to chronic disease and therapeutic drug interventions