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Thats a mechanistically different target than NSAIDs (nonsteroidal anti-inflammatory drugs), or corticosteroids, which partly explains why the compound has attracted interest in cases where conventional anti-inflammatory approaches have failed or created downstream problems

Inflamm Bowel Dis 2008;14:374-82

Prinsloo S, Rosenthal DI , Lyle R, Garcia SM, Gabel-Zepeda S, Cannon R, Bruera E, Cohen L

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I had terrible burning, urinary frequency and urgency, and the back pain worsened