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We confirm that co-treatment with 5FU and mitochondrial inhibitors, particularly CI inhibitors IACS-010759 (a specific CI inhibitor under clinical evaluation 51 ) and metformin hydrochloride (a treatment for diabetes that inhibits CI 52 ), increases growth arrest and death in CRC cells (Fig

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Consequently, any disruption of these subsistence food-gathering activities poses a serious threat to the integrity and maintenance of these cultures

[DOI] [PMC free article] [PubMed] [Google Scholar] 129.Heming M., Li X., Rauber S., Mausberg A.K., Borsch A.L., Hartlehnert M., Singhal A., Lu I.N., Fleischer M., Szepanowski F., et al

[9] With the standard regimen, we do not expect any liver issues or nerve issues