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This method demonstrated the medicinal promise of RTA-408, an artificial oleanane triterpene that inhibits oxidative stress and proinflammatory mediators, including NF-B and IFN-, by Nrf3/hO-1 activation

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GSH-dependent cytotoxicity and depletion of intracellular GSH After validating that NSBSO is highly sensitive to GSH treatment in vitro, we explored its cellular effect induced by this molecular and morphological transformation and the simultaneous GSH regulation by measuring the cell viability in cck-8 assay

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The Journal of Pharmacology and Experimental Therapeutics, 294 , 11201130