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In the TME, competition for glutamine between tumor cells and myeloid cell SLC1A5 transporters significantly promotes MDSC generation and recruitment, while inhibiting the formation of anti-tumor inflammatory TAMs, thus impairing anti-tumor immunity (79)

The role of mitochondria as a key target suggests a certain degree of interaction between cardiovascular disease and cognitive impairment, providing valuable guidance for future research and warranting further exploration

PMC 5353360

Discovery of 2-vinyl-10H-phenothiazine derivatives as a class of ferroptosis inhibitors with minimal human Ether-a-go-go related gene (hERG) activity for the treatment of DOX-induced cardiomyopathy

Pan R, Debose L, Benito JM, Golfman LS, Zweidler-McKay PA, Han L, Harutyunyan KG, Mu H, Ruvolo VR, Park E, Muschen M, Leverson J, Borthakur G , Kantarjian HM, Ruvolo PP, Andreeff M, Konopleva M

Glutathione Transferase U13 functions in pathogen-triggered glucosinolate metabolism