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Furthermore, oxidative and metabolic stress, negative energy balance, immune suppression, and diminished productive efficiency collectively undermine the overall productivity of these animals (3436)

Adv Exp Med Biol 500:1-10, 2001

Persistent elevations in blood glucose activate several interconnected biochemical and molecular pathways, including the polyol pathway, the formation of AGEs, activation of protein kinase C, the hexosamine biosynthetic pathway, excessive oxidative stress, and epigenetic modifications

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However, a frequently encountered question by researchers who study the bilateral cavernous nerve injury (BCNI) model is whether the nNOS changes in the DPNs of rats could represent CN injury