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observed upregulation of HAMP in mice subjected to MIRI and demonstrated that sodium-glucose cotransporter 2 inhibitors (SGLT2i) modulate macrophage polarization to suppress HAMP expression, thereby reducing cardiac iron levels and attenuating myocardial fibrosis [89]

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Fibrosis was promoted in WT LFD CA and DKO HFHSD CA and DCA compared to respective vehicle groups per genotype

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(Weinh) 11 (20), e2307319