glutathione exhausing effect nanoparticle Frontiers Facile fabrication of glutathione-responsive and

Cindella: Cindella presents a potent solution of thioctic (-lipoic) acid, a robust antioxidant that shields cell membranes from oxidative stress

The net G of the coupled reaction is 16.7 kJ/mol (4.0 kcal/mol)

2.5 Langendorff isolated heart perfusion protocol Langendorff isolated rat heart model was used to study myocardial resistance to ischemia/reperfusion (I/R)

The latter finding is in accordance with the unaltered GSH content as well as the absence of overt signs of oxidative stress that we previously reported in the hippocampus of adult and aged xCT / mice [7], confirming earlier findings that system x c is not critical for the synthesis of GSH in vivo and alternative pathways are active to maintain the (intracellular) levels of cysteine and GSH [44]

References 1 AdessoS.MagnusT.CuzzocreaS.CampoloM.RissiekB.PacielloO.et al

Data availability The datasets analyzed during the current study are not publicly available due to concerns regarding participant privacy and consent, but are available from the corresponding author upon reasonable request