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Plasma insulin-like growth factor binding protein 1 in pulmonary arterial hypertension

It was clinically approved by both the Food and Drug Administration (FDA) and the European Medicine Agency (EMA) in 2014 for the treatment of relapsing-remitting multiple sclerosis (MS), showing a significant efficacy over 2 years versus placebo and a favorable benefit-risk profile in two phase-III clinical trials, although with several adverse effects such as nausea, diarrhea, abdominal pain and leukopenia in some patients [282, 283]

Inhibition of Tumor Propellant Glutathione Peroxidase 4 Induces Ferroptosis in Cancer Cells and Enhances Anticancer Effect of Cisplatin

80% of the supernatant was transfered to a new tube using an electric pipette without disturbing the pellet, and then filtered through a 0.22 m filter (Merck, #SLGPR33RB) as described previously 84,85

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Reactive oxygen species can rapidly convert nitric oxide into peroxynitrite, a damaging compound that reduces vascular signaling efficiency and increases cellular damage