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Introduction T cells are essential components of adaptive immunity, recognizing antigens presented by antigen-presenting cells and executing effector functions ranging from cytokine production to cytotoxic activity (13)

For patients with symptomatic liver disease, improvement in synthetic function and clinical signs such as jaundice and ascites begins during the first 26 months of treatment, with further recovery possible over time

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344 Similarly, miR-182-5p overexpression in hepatocytes increases cholic acid production by activating cholesterol 7 alpha-hydroxylase (CYP7A1), driving HSCs to secrete Hedgehog and stimulating hepatocyte proliferation following PHx

To further test the ability of gliT to confer resistance to gliotoxin, and its future potential as a selection marker gene, we introduced gliT into A

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