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Introduction G protein-coupled receptors (GPCRs) 1 represent the largest and most diverse superfamily of membrane proteins in human, comprising over 800 members 2

Hepatorenal syndrome ( P =0.02) and infections ( P =0.001) were less frequent in the combination therapy at 6 months [54]

Lower baseline CSF -synuclein levels in the DATATOP study predicted a better preservation of cognitive function in early PD patients with up to 8 years of follow-up (Stewart et al., 2014)

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In older patients or those who are immunocompromised, skin preparation using an alcohol-impregnated (70% isopropyl alcohol) swab may be recommended (Lister et al, 2020)