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3: Matek D, Matek I, Japjec M, Matek M, Prenc J, Staresinic B, Staresinic E, Prtoric A, Sikiric S, Beketic Oreskovic L, Oreskovic I, Strbe S, Kordic M, Tvrdeic A, Seiwerth S, Sikiric P, Boban Blagaic A, Skrtic A, Bojanic I, Dobric I, Staresinic M

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found that in a rat rotator cuff tear model, a self-healing hydrogel releasing curcumin and Mg 2+ synergistically promoted tendon-to-bone healing by reducing inflammation and oxidative stress while enhancing stem cell chondrogenesis, fibrocartilage formation, and biomechanical strength ( in vitro human tenocyte model, tannic acid-coated curcumin-loaded acetalated dextran nanoparticles (TA-Cur-AcDEX NPs) developed via microfluidics showed strong anti-inflammatory and anti-fibrotic effects, significantly downregulating NF-B, TGF-, and MMP-3/9 expression while enhancing nanoparticle stability, uptake, and biocompatibility (Molinaro et al., 2023)