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4.5.2 Mechanism of action in dry eye disease Spermidine helps regulate the immune systems balance, crucial in conditions like DED, where inflammation plays a key role

Unlike the traditional approach whereby data are obtained from individuals deemed healthy, these investigators applied an indirect method designed to overcome the ethical and resourcing difficulties experienced when sampling apparently healthy individuals

Nat Genet 1:368371 Reardon W, Ross RJ, Sweeney MG, Luxon LM, Pembrey ME, Harding AE, Trembath RC (1992) Diabetes mellitus associated with a pathogenic point mutation in mitochondrial DNA