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doi:10.1111/j.1751-1097.2011.01022.x Hu J, Wang T, Zhou L, Wei S

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Hypoxia-inducible factor-1 induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition

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However, several studies also showed a narrow therapeutic window, with excessive ozone concentrations leading to cytotoxicity and endothelial dysfunction, particularly in culture systems with compromised redox buffering