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Biological therapies, especially anti-TNF therapy are effective treatments, but the primary lack of response to TNF inhibitors or the secondary loss of response among some patients requires the search for new therapeutic solutions [121,122,123]

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In cases of severe B vitamin deficiency, Methylcobalamin injections are highly recommended

It works by regulating the brains sleep mechanisms, influencing circadian rhythms, and reducing stress-related cortisol

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Low B12 levels during pregnancy have been associated with an increased risk of low birth weight, preterm birth and miscarriage