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Improving the supply of raw materials for GSH systems The direct administration of GSH in vivo is probably an obvious way to increase GSH It has been demonstrated that modified oral glutathione-like liposomal GSH increases erythrocyte and plasma GSH levels and reduces oxidative stress biomarkers [98]

10.1016/j.bbrc.2019.05.147 173 XieX.MaX.ZengS.TangW.XiaoL.ZhuC.et al (2020)

Endogenous redox sensors ( e.g

[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Pirozzi F.F., Belini Junior E., Okumura J.V., Salvarani M., Bonini-Domingos C.R., Ruiz M.A

Phospholipase iPLA(2) averts ferroptosis by eliminating a redox lipid death signal

Although the time course of Nrf2 stabilization and nuclear translocation indicated a rapid increase with a peak at approximately 6 h for DEM, and a slow but gradual rise triggered by NFT, maximal accumulation of Nrf2 protein, as well as the induction of GCLC and glutathione synthesis, were almost identical for both NFT and DEM after incubation periods of and beyond 24 h (Fig