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1,2-Di-O-tetradecyl-sn-glyceride Ia (30 g, 61.80 mmol) and N,N-succinimidylcarbonate (DSC, 23.76 g, 1.5 eq) were taken in dichloromethane (DCM, 500 mL) and stirred over an ice water mixture

Cardiac-specific overexpression of acyl-CoA synthetase-1 (ACSL1) in mice has been shown to mitigate pressure overload-induced cardiac dysfunction by reducing toxic lipid accumulation, restoring long-chain acyl-CoA levels, and enhancing mitochondrial bioenergetics

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We detected a significant reduction of the dehydrogenase activity after incubation with all tested compounds at the highest concentrations