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This observed neuroprotective effect of HGF on dopaminergic (DA) neurons meshes with its ability to augment the proliferation and migration of dopaminergic progenitor cells (Lan et al., 2008) The neuroprotective effect of the HGF on the nigrostriatal pathway, however, should be no surprise given its recognized role in stem cell regulation, the development of tubular structures (Santos et al., 1993) and its general proliferative, anti-apoptotic, motogenic, and morphogenic actions on many cell types including hepatocytes and cells of epithelial origin (Gherardi et al., 1993)

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10.1038/onc.2012.433 Oncogene 95 VerduciL.TarcitanoE.StranoS.YardenY.BlandinoG

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Provides antiseptic and astringent benefits, antibiotic actions to reduce the spread of bacteria, and circulation stimulation

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USA 95 , 67056710 (1998)

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Gain of methylation at IC1 (IC1 GOM) leads to biallelic IGF2 expression, loss of methylation at IC2 (IC2 LOM) leads to decreased CDKN1C expression and paternal uniparental isodisomy of chromosome 11p15 (pUPD11) leads to both increased IGF2 expression and decreased CDKN1C expression 3

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