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Preclinical Observations Findings observed in murine studies include: Endurance capacity: Increased treadmill running time and distance Mitochondrial function: Enhanced respiration and ATP production in muscle Cardiac metabolism: Improved fatty acid utilization in models of heart failure Renal function: Reduced mitochondrial dysfunction and inflammation in aging kidney models Metabolic profile: Improved glucose handling in metabolic syndrome models These results are limited to animal models using intraperitoneal injection

For patients without absorption disorders, high-dose oral supplements of 1,000 to 2,000 mcg daily have been shown to be comparably effective at correcting mild to moderate deficiency at lower cost and greater convenience.

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Vitamin C helps brighten the skin, reduce dark spots, and protect against oxidative stress while it promotes skin repair and rejuvenation

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