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Sonthalia S, Daulatabad D, Sarkar R

pii: S0022-5347(18)42817-0

Mitchell et al.[6] measured the level of GSH depletion in the liver (of mice), and the amount of covalent binding of radiolabeled APAP metabolites (later identified as NAPQI) in the liver after a wide range of doses of APAP

doi: 10.7554/elife.01202 170 ZhangXZhangDJiaHFengQWangDLiangDet al

Similarly, inhibition of mTOR reduces the levels of glycine, asparagine, glutamine, and proline, all of which are essential for fibroblast activation and matrix deposition [111]