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it is a severe adverse effect that can limit dose and choice of chemotherapy Many substances already approved for treating neuropathic pain failed to ameliorate CIPNP in clinical trials, underlining the importance of assessing drug efficacy in CIPNP independently of other neuropathic pain states CIPNP has distinctive mechanisms that depend on the causative cytostatic drug

Usha Nagarajan, Central University of Haryana (CUH), India Updates Copyright 2020 Zhang, Wang, Lian, Zhang and He

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Moreover, L-carnitine counteracted the inhibitory action of lenvatinib on global protein synthesis in C2C12 myocytes, the major mechanism considered for preventive effect of L-carnitine against lenvatinib-induced muscle toxicity

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