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One trial used 2000 g/day vitamin B 12 and demonstrated a mean difference of 680 pg/mL (95% confidence interval 392.7 to 967.3) in favor of oral vitamin B 12

These drugs independentlyand synergisticallyinduce severe B12 deficiencies by disrupting entirely different stages of the digestive process

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The Initial Boost: What to Expect After Your First Shot If youve been diagnosed with a significant B12 deficiency, your GP will likely prescribe an initial course of injections, often called a loading dose phase