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In some research contexts, observations have included mild and transient tolerability-related effects such as: Headaches Nausea Stimulation-related observations Temporary injection-site irritation or localized skin-response variability Research conditions, concentration ranges, dosage ranges, hydration status, administration frequency, and protocol structure may influence tolerability observations across experimental settings

Antioxidants (Basel) (2021) 10(1):98

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The typical COPD patient is just as likely to die from both respiratory and cardiovascular causes [125]