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These tumors exhibit dependencies on serine hydroxymethyltransferase (SHMT)-mediated pathways that represent novel therapeutic vulnerabilities [64, 65]

J Neurochem 2009

ROS may be a general modulator of NF-B signaling pathway activation (51)

showed that Gpx4BIKO mice display spatial learning deficits, hippocampal neurodegeneration, and increased markers of ferroptosis, including lipid peroxidation, ERK activation, and neuroinflammatory responses (289)