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The roles of lipid and glucose metabolism in modulation of -amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease

Perspective: vitamin D deficiency and COVID-19 severity plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2, and thrombosis (R1)

Fahey MC, Cremer PD, Aw ST, Millist L, Todd MJ, White OB, Halmagyi M, Corben LA, Collins V, Churchyard AJ, Tan K, Kowal L, Delatycki MB

In the previously cited clinical study,9 the elderly subjects received 100 mg/kg of both NAC and glycine for 14 days, and their red blood cell total glutathione levels (reduced glutathione plus diglutathione) rose from 1.26 mmol/L at baseline to 2.23 mmol/L, a concentration slightly higher than that measured in young subjects who did not take supplements.9 Moreover, the ratio of reduced glutathione to diglutathione rose from 7.4:1 to 16.1:1, indicative of a substantial improvement in redox status as confirmed by concurrent reductions in plasma markers of oxidative stress

The mRNA levels of GCLC and GS were both lower (50% and 30%, respectively) while mRNA levels of GCLM were unchanged

219 Together with its upstream regulators and downstream effectors, mTORC1 plays a significant role in regulating mitochondrial fission and fusion (Fig