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10.1186/s13395-019-0209-y 3 ArgilsJ

The most consistent results so far are grey matter alterations in the basal ganglia, areas of the limbic system such as the anterior cingulate cortex, hippocampus, insula, etc., and prefrontal areas like the orbitofrontal cortex, sometimes even more pronounced in association with self-reported fatigue or neurocognitive impairment [12, 35, 49]

Unlike oral supplements, which face the gauntlet of our digestive system (and often get broken down, resulting in as little as 20-50% absorption), intravenous delivery bypasses the gut entirely

Geyer, J

Because lipo c with b12 is not FDA approved for weight loss, human safety data for the combined injectable formulation is limited