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While in the present study we did not include a group of untreated 5xFAD mice, our previous experience revealed no differences between untreated and IgG-injected mice, neither in the 5xFAD 54 nor DM-hTAU 40 mouse models

Zhang J, Guo P, Qiu M, Zhong G, Yang Q, Lei P, Gou K, Zeng R, Zhang C, Qu Y

Similarly, CD38 inhibitors, such as 78C, protect against cardiomyocyte senescence by preserving NAD+ [19]

Targeting CD44 hinders relevant signaling pathways associated with these activities

In this study, we investigated the protective effect of CPI2 against MSU-induced gouty arthritis using wild-type (WT) and C5aR1 knockout (C5aR1 / ) mice and preliminarily evaluated the underlying mechanisms