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These possible complications include the following: Birth defects, miscarriage, or premature birth if taken during pregnancy Joint or bone pain, abnormal bone growth, and osteoporosis (bone thinning or weakening) Visual issues, including reduced night vision Hearing impairment Rare buildup of pressure inside the head (pseudotumor cerebri), with symptoms like blurred vision and nausea Mental health challenges like mood swings, depression, anxiety, or suicidal thoughts

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Inhibitors of FASN (such as TVB-2640, which has advanced to clinical trials) and acetyl-CoA carboxylase (ACC) inhibitors have shown preclinical efficacy in reducing tumor growth and overcoming resistance to targeted therapies

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It was reported that the alpha diversity of the gut microbiota was lower in the brain tumour patients, as indicated by decreased Shannon, Simpson and Chao1 indices