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Advantage : Neither (tie) Summary and Verdict# CagriSema and tirzepatide achieve remarkably similar weight loss (20.4% vs 20.9%) through fundamentally different dual mechanisms -- amylin/GLP-1 versus GIP/GLP-1

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Changes associated with the epigenetic, antioxidant, and immune mechanisms are slower to manifest and are best assessed through follow-up body composition and lab data rather than subjective experience alone

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