napqi and glutathione Alcohol paracetamol are both processed through the liver. Paracetamol can form a toxic metabolite called NAPQI, which the body usually neutralises safely. But factors like heavy alcohol use, repeated dosing, fasting Acetaminophen metabolism. NAPQI, N-acetyl-p-benzoquinone imine;

Acetaminophen metabolism. NAPQI, N acetyl p benzoquinone imine; CYP450, Download Scientific Diagram Acetaminophen (PARACETAMOL) INTOXICATION May Hospital, Shendam Acetaminophen metabolism and NAPQI mediated mitochondrial effects Download Scientific Diagram Hepsin as a potential therapeutic target for alleviating acetaminophen induced hepatotoxicity via gap junction regulation and oxidative stress modulation Cell Biology and Toxicology Springer Nature Link Interaction with Ethanol Alcohol Metabolism 5 Antidote: NAC (N acetylcysteine) NAC replenishes glutathione, restoring the ability to detoxify NAPQI. It's lifesaving if given early. Example: Hospitals use NAC as the standard treatment for APAP overdose.

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