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Call a healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying attempts to commit suicide new or worse depression new or worse anxiety feeling very agitated or restless panic attacks trouble sleeping (insomnia) new or worse irritability acting aggressive, being angry, or violent acting on dangerous impulses an extreme increase in activity and talking (mania) other unusual changes in behavior or mood Low salt (sodium) levels in the blood.Elderly people may be at greater risk for this

doi: 10.1007/164_2018_167

Another class of drugs has been explored for PD management is histone deacetylase 6 (HDAC6) inhibitors such as such as CAY10603 and Tubastatin A which enhance the -synuclein aggregates clearance to mitigate neurodegeneration 17,62

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