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These contaminants can come from soil, water, or manufacturing processes and may accumulate in the body over time

Simulation system equilibration and energy minimization Following preparation, the systems were energy minimized with an energy tolerance of 100 kj/mol and equilibrated in six sequential steps involving loosening of positional restraints on lipid atoms, protein backbone atoms, and protein side chain atoms (equilibration parameters in Extended Data Table 2)

doi: 10.1038/s41419-023-05708-0 16 ChenHHanZWangYSuJLinYChengXet al

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While at the 30 min and 9 h time points around 40 % of the genes were downregulated, the proportion of downregulated genes at 1 h decreased to 23 %